CD86 / Unconjugated / SPM600

Product Details
Supplier NSJ Bioreagents
Catalog #: V2989SAF-100UG (View supplier product page)
Size 100 μg
Price $554.00
Antigen CD86
Clone SPM600
Host Mouse
Isotype IgG
Conjugate Unconjugated
Target Species Human, Mouse, Rat
Applications IF, IHC-P
Description CD86 is a receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. [UniProt]
About CD86 and Purified
CD86 This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]
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Purified Excitation and Emission Spectra