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	Supplier	NSJ Bioreagents
	Catalog #:	V2409-20UG (View supplier product page)
	Size	20 μg
	Price	$252.00
	Antigen	CD45RA
	Clone	111-1C5
	Host	Mouse
	Isotype	IgG
	Conjugate	Unconjugated
	Target Species	Human
	Applications	FC, IF, WB, IHC-P
	Description	CD45RA is an isoform of the human leukocyte common antigen (CD45). Human CD45 contains three exons which encode peptide segments designated A, B and C, respectively. The differential splicing of the exons generates at least five isoforms, ABC, AB, BC, B and O. This antibody reacts with ABC and BC isoforms. CD45RA is expressed on 40-50% of peripheral CD4+ T-cells, 50% of peripheral CD8+ T-cells, B-cells, and leukemic B-cell lines. T-cells expressing CD45RA are naive or virgin T-cells. T-cells expressing CD45RO are memory T-cells. CD45RA and CD45RO define complementary, predominantly non-overlapping populations of resting peripheral T-cells. This MAb is useful in study on the subpopulation of CD4+ or CD8+ T-cells. It can especially be used to differentiate T-cell lymphomas (CD45RO +ve) from B cell lymphomas (CD45RA +ve).

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CD45RA / Unconjugated / 111-1C5