Calcineurin B / Unconjugated / BE2.1

Product Details
Supplier NSJ Bioreagents
Catalog #: V8029-20UG (View supplier product page)
Size 20 μg
Price $252.00
Antigen Calcineurin B
Clone BE2.1
Host Mouse
Isotype IgG
Conjugate Unconjugated
Target Species Human
Applications WB, IHC-P
Description Calcineurin is an enzyme that dephosphorylates serine and threonine residues in proteins. It is a heterodimer of a 59kDa catalytic A subunit and a 19kDa regulatory B subunit that is activated by the binding of calcium ions and calmodulin. Calcineurin is expressed in many tissues, but its levels are highest in the brain, where it may play a role in learning and memory. It has many substrates, including NFAT, a transcription factor that is activated by dephosphorylation. Complexes of the immuno-suppressants cyclosporine and FK506 with immunophilin proteins such as cyclophilin and FKBP12 are potent and specific inhibitors of Calcineurin activity. Alterations in Calcineurin activity are suspected to play a role in cardiac hypertrophy and graft versus host disease in organ transplantation.
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Purified Excitation and Emission Spectra