14-3-3 sigma / Unconjugated / CPTC-SFN-2

Product Details
Supplier NSJ Bioreagents
Catalog #: V3999-20UG (View supplier product page)
Size 20 μg
Price $252.00
Antigen 14-3-3 sigma
Clone CPTC-SFN-2
Host Mouse
Isotype IgG
Conjugate Unconjugated
Target Species Human
Applications WB, IHC-P
Description SFN (Stratifin), also called 14-3-3 Sigma, is a p53-induced tumor suppressor gene which is activated in response to DNA damage, causing cell cycle arrest at G2 phase by blocking cdc2-cyclin B1 complex from entering the nucleus. It is inactivated in breast, lung, prostate, liver and gastric cancer. It is associated with poor prognosis when its down-regulation is observed in epithelial ovarian cancer. SFN expression could contribute to cancer cell proliferation and the development and/or progression of human gastrointestinal cancer.
About 14-3-3 sigma and Purified
14-3-3 sigma This gene encodes a cell cycle checkpoint protein. The encoded protein binds to translation and initiation factors and functions as a regulator of mitotic translation. In response to DNA damage this protein plays a role in preventing DNA errors during mitosis. [provided by RefSeq, Aug 2017]
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Purified Excitation and Emission Spectra