SMC1 / Unconjugated /

Product Details
Supplier Biorbyt
Catalog #: orb106500-20ul (View supplier product page)
Size 20 μl
Price $256.70
Antigen SMC1
Clone
Host Rabbit
Isotype IgG
Conjugate Unconjugated
Target Species Human, Mouse
Applications IHC-P, WB
Description Rabbit polyclonal to SMC1. Smc1 ia a component of the cohesin multiprotein complex that is required for sister chromatid cohesion. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Thought to be an important part of functional kinetochores.
About SMC1 and Purified
SMC1 Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
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Purified Excitation and Emission Spectra