ZnT-8 FLLSLFSLWL (Dextramer) / FITC /

Product Details
Supplier Biorbyt
Catalog #: orb158829-FITC (View supplier product page)
Size 100 ug
Price $445.40
Antigen ZnT-8 FLLSLFSLWL (Dextramer)
Clone
Host Rabbit
Isotype IgG
Conjugate FITC
Target Species Human, Mouse, Rat
Applications ICC, IF
Description Rabbit polyclonal antibody to ZNT8 -
About ZnT-8 FLLSLFSLWL (Dextramer) and FITC
ZnT-8 FLLSLFSLWL (Dextramer) The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]
FITC Fluorescein isothiocyanate (FITC) has an excitation peak at 495 nm and an emission peak at 519 nm. The name FITC is a misnomer in that the isothiocyanate is a reactive form of this dye. Once FITC is conjugated to an antibody, it is simply Fluorescein conjugated. FITC is one of the most widely used dyes for fluorescent applications, therefore most instruments come standard with a 488 nm laser and FITC filter set up. FITC is commonly conjugated to secondary antibodies and used in applications such as flow cytometry, immunocytochemistry, and immunohistochemistry. FITC is relatively dim, sensitive to photobleaching and it is susceptible to changes is pH. There are better performing alternatives to FITC, like Vio®Bright 515, Alexa Fluor™ 488, iFluor® 488, CF®488A and DY-488. FITC is a long-time generic dye with no sole manufacturer or trademark.
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FITC Excitation and Emission Spectra