Von Willebrand Factor / CF647 /

Product Details
Supplier Biorbyt
Catalog #: orb158717-CF647 (View supplier product page)
Size 100 ug
Price $479.40
Antigen Von Willebrand Factor
Clone
Host Rabbit
Isotype IgG
Conjugate CF647
Target Species Human, Mouse, Rat
Applications ICC, IF
Description Rabbit polyclonal antibody to VWF, which is also known as F8VWF and VWD. VWF is frequently found in the extracellular matrix and is expressed in the Whartons jelly-derived stem cells of placenta and mesodermal cells. It is overexpressed in the monocytes and peripheral blood mononuclear cells. It extensively acts as a chaperone for coagulation factor VIII and delivering it to the site of injury for stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. This protein is important in the maintenance of hemostasis and also promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. -
About Von Willebrand Factor and CF647
Von Willebrand Factor This gene encodes a glycoprotein involved in hemostasis. The encoded preproprotein is proteolytically processed following assembly into large multimeric complexes. These complexes function in the adhesion of platelets to sites of vascular injury and the transport of various proteins in the blood. Mutations in this gene result in von Willebrand disease, an inherited bleeding disorder. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Oct 2015]
CF647 CF®647 from Biotium is a fluorophore with an excitation peak at 642 nm and an emission peak at 662 nm. It can be useful in both fluorescence microscopy and flow cytometry. It is spectrally similar to Alexa Fluor™ 647, DyLight™ 649 and Cy5.
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CF647 Excitation and Emission Spectra