PAK2 / Unconjugated /

Product Details
Supplier Biorbyt
Catalog #: orb67263 (View supplier product page)
Size 100 ul
Price $656.20
Antigen PAK2
Clone
Host Rabbit
Isotype IgG
Conjugate Unconjugated
Target Species Human, Mouse
Applications WB
Description Rabbit polyclonal to PAK2.p21-activated kinase 2 (PAK2) belongs to the protein kinase superfamily, STE Ser/Thr protein kinasefamily and STE20 subfamily. PAK2 plays a role in a variety of different signaling pathways includingcytoskeleton regulation, cell motility, cell cycle progression, apoptosis and proliferation. PAK2 acts asdownstream effector of the small GTPases CDC42 and RAC1. Activation of PAK2 by the binding ofactive CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylationof PAK2. Activated PAK2 can phosphorylate many substrates including histone H4, BAD, ribosomalprotein S6 and MBP. Additionally, PAK2 associates with ARHGEF7 to perform kinaseindependentfunctions such as spindle orientation control during mitosis. On the other hand, apoptoticstimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34 thattranslocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway. -
About PAK2 and Purified
PAK2 The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008]
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Purified Excitation and Emission Spectra