GRP78 / ATTO 488 /

Product Details
Supplier Biorbyt
Catalog #: orb151802 (View supplier product page)
Size 100 ug
Price $601.80
Antigen GRP78
Clone
Host Rabbit
Isotype IgG
Conjugate ATTO 488
Target Species Human, Mouse, Rat
Applications WB, ICC
Description Rabbit polyclonal to GRP78 antibody (ATTO-488) -
About GRP78 and ATTO 488
GRP78 The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. This protein localizes to the lumen of the endoplasmic reticulum (ER) where it operates as a typical HSP70 chaperone involved in the folding and assembly of proteins in the ER and is a master regulator of ER homeostasis. During cellular stress, as during viral infection or tumorogenesis, this protein interacts with the transmembrane stress sensor proteins PERK (protein kinase R-like endoplasmic reticulum kinase), IRE1 (inositol-requiring kinase 1), and ATF6 (activating transcription factor 6) where it acts as a repressor of the unfolded protein response (UPR) and also plays a role in cellular apoptosis and senescence. Elevated expression and atypical translocation of this protein to the cell surface has been reported in viral infections and some types of cancer cells. At the cell surface this protein may facilitate viral attachment and entry to host cells. This gene is a therapeutic target for the treatment of coronavirus diseases and chemoresistant cancers. [provided by RefSeq, Jul 2020]
ATTO 488 ATTO 488 is from ATTO-Tec Gmbh has an excitation peak at 501 nm and an emission peak at 523 nm.
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ATTO 488 Excitation and Emission Spectra