Mortalin / ATTO 488 / S52A-42

Product Details
Supplier Biorbyt
Catalog #: orb147100 (View supplier product page)
Size 100 μg
Price $625.60
Antigen Mortalin
Clone S52A-42
Host Mouse
Isotype IgG1
Conjugate ATTO 488
Target Species Human, Rat
Applications IHC-P, IP, WB
Description Mouse monoclonal to Grp75 (ATTO-488). Grp75, also known as mortalin, is a member of Hsp70 family of chaperone proteins that is not heat inducible. Grp75 is actually induced under conditions of low glucose and other nutritional and environmental stresses. Grp75 resides primarily in the mitochondrial matrix, where it collaborates with Hsp60 in the re-folding of proteins translocated into this organelle. Related forms may also be found in the cytosol or on the surface of the extracellular membrane. Other Grp75 functions include its ability to inactivate the tumor suppressor p53. Studies have found that Grp75 is over-expressed in many tumor tissues and immortalized human cell lines, suggesting its role in the tumor formation. Grp75 is also implicated in cell aging, as its overexpression appears to prolong the life span of human fibroblasts. And finally, like its E. coli homolog DnaK, GRP75 possesses a cation-dependent ATPase activity considered central to its function as a chaperone (9, 10)..
About Mortalin and ATTO 488
Mortalin This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13. [provided by RefSeq, Aug 2011]
ATTO 488 ATTO 488 is from ATTO-Tec Gmbh has an excitation peak at 501 nm and an emission peak at 523 nm.
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ATTO 488 Excitation and Emission Spectra