GFAP / ATTO 488 / S206A-8

Product Details
Supplier Biorbyt
Catalog #: orb150516 (View supplier product page)
Size 100 ug
Price $646.00
Antigen GFAP
Clone S206A-8
Host Mouse
Isotype IgG1
Conjugate ATTO 488
Target Species Human, Mouse, Rat
Applications ICC, WB, IHC
Description Mouse monoclonal to GFAP (ATTO-488). The 50 kDa type III intermediate filament protein glial fibrillary acidic protein (GFAP) is a major structural component of astrocytes. GFAP associates with the calcium binding protein annexin II-p2 and S-100. Association with these proteins together with phosphorylation regulates GFAP polymerization. Astroycytes respond to brain injury by proliferatin (astrogliosis), and one of the first events to occur during astrocyte proiliferation is increased GFAP expression. Interestingly, antibodies to GFAP have been detected in individuals with dementia.. -
About GFAP and ATTO 488
GFAP This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
ATTO 488 ATTO 488 is from ATTO-Tec Gmbh has an excitation peak at 501 nm and an emission peak at 523 nm.
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ATTO 488 Excitation and Emission Spectra