Dnmt1 / ATTO 390 / 11H8

Product Details
Supplier Biorbyt
Catalog #: orb376765 (View supplier product page)
Size 100 ug
Price $632.40
Antigen Dnmt1
Clone 11H8
Host Mouse
Isotype IgG1
Conjugate ATTO 390
Target Species Human, Mouse
Applications WB, ICC
Description Mouse monoclonal antibody against DNMT1 conjugated to ATTO-390. -
About Dnmt1 and ATTO 390
Dnmt1 This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
ATTO 390 ATTO 390 from ATTO-TEC has an excitation peak at 390 nm and an emission peak at 448 nm. It is a novel fluorescent label with a coumarin structure. Characteristic features of the label are high fluorescence quantum yield, large Stokes-shift, good photo-stability, and low molecular weight.
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ATTO 390 Excitation and Emission Spectra