ATP7b / ATTO 488 / S62-29

Product Details
Supplier Biorbyt
Catalog #: orb149801 (View supplier product page)
Size 100 ug
Price $646.00
Antigen ATP7b
Clone S62-29
Host Mouse
Isotype IgG1
Conjugate ATTO 488
Target Species Human, Mouse, Rat
Applications IP, WB, ICC, IHC
Description Mouse monoclonal to Copper Transporting ATPase 2 (ATTO-488). The copper efflux transporters ATP7A and ATP7B sequester intracellular copper into the vesicular secretory pathway for export from the cell. ATP7b is an important protein for copper transport and elimination of excess copper from the body. ATP7b transports metals in and out of cells using ATP. There are 3 known isoforms of the ATP7b gene; A is found in the liver, kidney, and brain, the shorter form B is found in brain tissue, and the third isoform, known as WND/140 KDA is found in mitochondria. Mutations in the ATP7b gene can cause Wilson's disease, an inherited disorder causing copper poisoning in the brain and liver, characterized by neurological symptoms and hepatic damage.. -
About ATP7b and ATTO 488
ATP7b This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein is a monomer, and functions as a copper-transporting ATPase which exports copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease which is characterized by copper accumulation. [provided by RefSeq, Dec 2019]
ATTO 488 ATTO 488 is from ATTO-Tec Gmbh has an excitation peak at 501 nm and an emission peak at 523 nm.
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ATTO 488 Excitation and Emission Spectra