Capicua / Biotin /

Product Details
Supplier Biorbyt
Catalog #: orb215554-Biotin (View supplier product page)
Size 100 &mu
Price $448.80
Antigen Capicua
Clone
Host Rabbit
Isotype IgG
Conjugate Biotin
Target Species Human, Mouse, Rat
Applications ICC, IF
Description Rabbit polyclonal antibody to CIC -
About Capicua and Biotin
Capicua The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]
Citations
Additional
Sources
Reviews & Ratings
Submit a Review

Biotin Excitation and Emission Spectra