CBL / Unconjugated / 3B12

Product Details
Supplier Biorbyt
Catalog #: orb314620 (View supplier product page)
Size 50 μl
Price $725.90
Antigen CBL
Clone 3B12
Host Mouse
Isotype IgG1
Conjugate Unconjugated
Target Species Human, Rat
Applications ELISA, FC, ICC, IF, IHC-P, WB
Description Mouse monoclonal antibody to CBL
About CBL and Purified
CBL This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Jul 2016]
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Purified Excitation and Emission Spectra