Bestrophin 1 / Unconjugated /

Product Details
Supplier Biorbyt
Catalog #: orb394759 (View supplier product page)
Size 100 ug
Price $452.20
Antigen Bestrophin 1
Clone
Host Mouse
Isotype IgG2a
Conjugate Unconjugated
Target Species Human
Applications ELISA, WB
Description Mouse monoclonal antibody to BEST1.
About Bestrophin 1 and Purified
Bestrophin 1 This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Nov 2008]
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Purified Excitation and Emission Spectra