HSD11B2 / Unconjugated /

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NB100-75626-0.025mg (View supplier product page)
Size 0.025 mg
Price $248.00
Antigen HSD11B2
Clone
Host Chicken
Isotype IgG
Conjugate Unconjugated
Target Species Human, Primate, Rat
Applications WB
Description HSD11B2 Antibody
About HSD11B2 and Purified
HSD11B2 There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq, Feb 2010]
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Purified Excitation and Emission Spectra