ErbB2 / APC-Cy7 / 4D5-8 (trastuzumab)

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-75895APCCY7 (View supplier product page)
Size 0.1 ml
Price $579.00
Antigen ErbB2
Clone 4D5-8 (trastuzumab)
Host Human
Isotype IgG1 κ
Conjugate APC-Cy7
Target Species Human
Applications FC
Description ErbB2/Her2 Antibody (4D5-8 (trastuzumab)) [Allophycocyanin/Cy7]
About ErbB2 and APC-Cy7
ErbB2 This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
APC-Cy7 APC-Cy7 (APC-Cyanine 7) has an excitation peak at 650 nm and an emission peak at 785 nm, and is spectrally similar to APC-CF®750 (Biotium), APC-H7 (BD Biosciences), APC-eFluor™ 780 (Thermo Fisher Scientific), APC-Vio®770 (Miltenyi Biotec) and APC-Fire™ 750 (BioLegend). This dye is a member of the Cyanine® dye family, a trademark of GE heathcare.
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APC-Cy7 Excitation and Emission Spectra