Cyclin D1 / DyLight 755 / CCND1/3370R

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP3-08955IR (View supplier product page)
Size 100 ul
Price $519.00
Antigen Cyclin D1
Clone CCND1/3370R
Host Rabbit
Isotype IgG
Conjugate DyLight 755
Target Species Human
Applications IHC, IHC-P
Description Cyclin D1 Antibody (CCND1/3370R) [DyLight 755]
About Cyclin D1 and DyLight 755
Cyclin D1 The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of human cancers. [provided by RefSeq, Dec 2019]
DyLight 755 DyLight™ 755 has an excitation peak of 754 nm and an emission peak of 776 nm and is spectrally similar to Alexa Fluor™ 750. DyLight™ 755 is most commonly used in fluorescence micrscopy.
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DyLight 755 Excitation and Emission Spectra