SDHB / Alexa Fluor 405 / SDHB/2126

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP3-08809AF405 (View supplier product page)
Size 100 ul
Price $519.00
Antigen SDHB
Clone SDHB/2126
Host Mouse
Isotype IgG1 κ
Conjugate Alexa Fluor 405
Target Species Human
Applications WB, IHC, IHC-P
Description SDHB Antibody (SDHB/2126) [Alexa Fluor 405]
About SDHB and Alexa Fluor 405
SDHB This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed of four nuclear-encoded subunits. This enzyme complex converts succinate to fumarate which releases electrons as part of the citric acid cycle, and the enzyme complex additionally provides an attachment site for released electrons to be transferred to the oxidative phosphorylation pathway. The SDH enzyme complex plays a role in oxygen-related gene regulation through its conversion of succinate, which is an oxygen sensor that stabilizes the hypoxia-inducible factor 1 (HIF1) transcription factor. Sporadic and familial mutations in this gene result in paragangliomas, pheochromocytoma, and gastrointestinal stromal tumors, supporting a link between mitochondrial dysfunction and tumorigenesis. Mutations in this gene are also implicated in nuclear type 4 mitochondrial complex II deficiency. [provided by RefSeq, Jun 2022]
Alexa Fluor 405 Alexa Fluor™ 405 (AF405, Alexa 405) has an excitation peak at 401 nm and an emission peak at 421 nm and is similar in size, brightness and application to ABflo 405® (ABclonal) and Cascade Blue® (ThermoFisher Scientific). Alexa 405 is commonly used in flow cytometery and fluorescence microscopy applications.
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Alexa Fluor 405 Excitation and Emission Spectra