alpha 2 Macroglobulin / DyLight 650 / A2M/3621

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP3-08688C (View supplier product page)
Size 100 ul
Price $519.00
Antigen alpha 2 Macroglobulin
Clone A2M/3621
Host Mouse
Isotype IgG2c κ
Conjugate DyLight 650
Target Species Human
Applications IHC, IHC-P
Description alpha 2-Macroglobulin Antibody (A2M/3621) [DyLight 650]
About alpha 2 Macroglobulin and DyLight 650
alpha 2 Macroglobulin The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016]
DyLight 650 DyLight™ 650 is a red-emitting fluorophore that excited by the 640 nm laser and collected using a 670/30 nm bandpass filter. DyLight™ 650 has an excitation peak at 652 nm and an emission peak at 672 nm, and is spectrally similar to Alexa Fluor™ 647 and Cy5. DyLight™ 650 is most commonly used in flow cytometery and fluorescence microscopy applications.
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DyLight 650 Excitation and Emission Spectra