CD23 / Unconjugated / REA1222

Product Details
Supplier Miltenyi Biotec
Catalog #: 130-126-484 (View supplier product page)
Size 100 µg in 100 µL
Price $205.00
Antigen CD23
Clone REA1222
Host Human
Isotype IgG1
Conjugate Unconjugated
Target Species Human
Applications Mass Cytometry, MICS (MACSima Imaging Cyclic Staining), IF, IHC
Description Clone REA1222 recognizes the human CD23 antigen, which is a 45 kDa type II transmembrane glycoprotein that belongs to the immunoglobulin family. It is expressed on most mature B cells, monocytes, follicular dendritic cells, and at low levels on T cells, Langerhans cells, eosinophils, and platelets. CD23 is thought to play a role in the regulation of B cell activation and IgE response. It is up-regulated upon B cell activation. The proteolytic cleavage of membrane CD23 can result in the release of soluble forms of the antigen (sCD23) with a reported biological activity. | Additional information: Clone REA1222 displays negligible binding to Fc receptors.
About CD23 and Purified
CD23 The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
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Purified Excitation and Emission Spectra