CD142 / Brilliant Ultraviolet 615 / HTF-1

Product Details
Supplier BD Biosciences
Catalog #: 751566 (View supplier product page)
Size 50 μg
Price $538.00
Antigen CD142
Clone HTF-1
Host Mouse
Isotype IgG1 κ
Conjugate Brilliant Ultraviolet 615
Target Species Human
Applications FC
Description Hu CD142 BUV615 HTF-1 50ug
About CD142 and Brilliant Ultraviolet 615
CD142 This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces, for example, on monocytes. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. Platelets and monocytes have been shown to express this coagulation factor under procoagulatory and proinflammatory stimuli, and a major role in HIV-associated coagulopathy has been described. Platelet-dependent monocyte expression of coagulation factor III has been described to be associated with Coronavirus Disease 2019 (COVID-19) severity and mortality. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Aug 2020]
Brilliant Ultraviolet 615 BD Horizon Brilliant™ UltraViolet 615 (BUV615) is a tandem dye has an excitation peak at 348 nm and has an emission maximum of 616 nm. This dye is part of the Brilliant™ UltraViolet dye family, developed and sold by BD Biosciences. This family of dyes uses BUV395 as the donor so that all dyes in the family can be excited by the 355 nm UV laser. Depending on the acceptor, the dyes in this family have different relative brightness ratings.
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Brilliant Ultraviolet 615 Excitation and Emission Spectra