CCR5 / Red 718 / 2D7/CCR5

Product Details
Supplier BD Biosciences
Catalog #: 752091 (View supplier product page)
Size 50 μg
Price $400.00
Antigen CCR5
Clone 2D7/CCR5
Host Mouse
Isotype IgG2a κ
Conjugate Red 718
Target Species Human
Applications FC
Description Hu CD195 R718 2D7/CCR5 50ug
About CCR5 and Red 718
CCR5 This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2015]
Red 718 Red 718 is excited by the 640 laser and emission captured by the 695/40 filter. It can be used with the following analysis platforms: Flow Cytometry.
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Red 718 Excitation and Emission Spectra