IL-4 / Red 718 / MP4-25D2

Product Details
Supplier BD Biosciences
Catalog #: 566980 (View supplier product page)
Size 100 Tests
Price $388.00
Antigen IL-4
Clone MP4-25D2
Host Rat
Isotype IgG1
Conjugate Red 718
Target Species Human
Applications FC
Description Hu IL-4 R718 MP4-25D2 100Tst
About IL-4 and Red 718
IL-4 The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. IL4 is considered an important cytokine for tissue repair, counterbalancing the effects of proinflammatory type 1 cytokines, however, it also promotes allergic airway inflammation. Moreover, IL-4, a type 2 cytokine, mediates and regulates a variety of human host responses such as allergic, anti-parasitic, wound healing, and acute inflammation. This cytokine has been reported to promote resolution of neutrophil-mediated acute lung injury. In an allergic response, IL-4 has an essential role in the production of allergen-specific immunoglobin (Ig) E. This pro-inflammatory cytokine has been observed to be increased in COVID-19 (Coronavirus disease 2019) patients, but is not necessarily associated with severe COVID-19 pathology. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Aug 2020]
Red 718 Red 718 is excited by the 640 laser and emission captured by the 695/40 filter. It can be used with the following analysis platforms: Flow Cytometry.
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Red 718 Excitation and Emission Spectra