RASSF1 / Janelia Fluor 646 /

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-97636JF646 (View supplier product page)
Size 0.1 ml
Price $369.00
Antigen RASSF1
Clone
Host Rabbit
Isotype IgG
Conjugate Janelia Fluor 646
Target Species Human
Applications IHC, ICC/IF, IHC-P
About RASSF1 and Janelia Fluor 646
RASSF1 This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, May 2011]
Janelia Fluor 646 Janelia Fluor® 646 was developed at the Janelia Campus of the Howard Hughes Medical Institute but is commercialized by other vendors. The Janelia Fluor®s family is unique in that the fluorophores are cell-permeable and are available in photoactivatable forms. These fluorophores were developed for super-resolution microscopy (STED, PALM and STORM) and live-cell microscopy in the HaloTag and SNAP-tag versions. Janelia Fluor® 646 has an excitation peak at 646 nm and an emission peak at 664 nm.
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Janelia Fluor 646 Excitation and Emission Spectra