p53 / CF680R / PCRP-TP53-2A10

Product Details
Supplier Biotium
Catalog #: BNC811924-100 (View supplier product page)
Size 100 μl
Price $170.00
Antigen p53
Clone PCRP-TP53-2A10
Host Mouse
Isotype IgG2b
Conjugate CF680R
Target Species Human
Applications IHC-P
Description p53 Tumor Suppressor Monoclonal Mouse Antibody (PCRP-TP53-2A10)
About p53 and CF680R
p53 This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]
CF680R CF®680R from Biotium is a fluorophore with an excitation peak at 680 nm and an emission peak at 701 nm. It can be useful in both fluorescence microscopy and flow cytometry. For microscopy, CF®680R has been specifically validated in super-resolution imaging by STORM, STED and 2-Photon microscopy. It is spectrally similar to Alexa Fluor™ 680, IRDye® 680 and Cy5.5.
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CF680R Excitation and Emission Spectra