p53 / CF405M / PCRP-TP53-2A10

Product Details
Supplier Biotium
Catalog #: BNC051924-500 (View supplier product page)
Size 500 μl
Price $470.00
Antigen p53
Clone PCRP-TP53-2A10
Host Mouse
Isotype IgG2b
Conjugate CF405M
Target Species Human
Applications IHC-P
Description p53 Tumor Suppressor Monoclonal Mouse Antibody (PCRP-TP53-2A10)
About p53 and CF405M
p53 This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]
CF405M CF®405M from Biotium is a fluorophore with an excitation peak at 408 nm and an emission peak at 452 nm. It is spectrally similar to Pacific Blue, V450 and DY-415. It can be use in fluorescence microscopy and flow cytometry. Specifically, it has been validated for use in STED, Structured Illumination (SIM) and 2-Photon microscopy. In flow cytometry, superior alternatives are Brilliant™ Violet 480, Brilliant™ Violet 510 and StarBright Violet 515.
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CF405M Excitation and Emission Spectra