ErbB2 / CF680R / ERBB2/2453

Product Details
Supplier Biotium
Catalog #: BNC812453-100 (View supplier product page)
Size 100 μl
Price $170.00
Antigen ErbB2
Clone ERBB2/2453
Host Mouse
Isotype IgG2a κ
Conjugate CF680R
Target Species Human
Applications IHC-P
Description HER-2 / c-ErbB-2 / Neu / CD340 Monoclonal Mouse Antibody (ERBB2/2453)
About ErbB2 and CF680R
ErbB2 This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
CF680R CF®680R from Biotium is a fluorophore with an excitation peak at 680 nm and an emission peak at 701 nm. It can be useful in both fluorescence microscopy and flow cytometry. For microscopy, CF®680R has been specifically validated in super-resolution imaging by STORM, STED and 2-Photon microscopy. It is spectrally similar to Alexa Fluor™ 680, IRDye® 680 and Cy5.5.
Citations
Additional
Sources
Reviews & Ratings
Submit a Review

CF680R Excitation and Emission Spectra