ErbB2 / CF543 / ERBB2/2453

Product Details
Supplier Biotium
Catalog #: BNC432453-100 (View supplier product page)
Size 100 μl
Price $170.00
Antigen ErbB2
Clone ERBB2/2453
Host Mouse
Isotype IgG2a κ
Conjugate CF543
Target Species Human
Applications IHC-P
Description HER-2 / c-ErbB-2 / Neu / CD340 Monoclonal Mouse Antibody (ERBB2/2453)
About ErbB2 and CF543
ErbB2 This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
CF543 CF®543 from Biotium is a fluorophore with an excitation peak at 541 nm and an emission peak at 560 nm. It can be useful in both fluorescence microscopy and flow cytometry.
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CF543 Excitation and Emission Spectra