CD25 / CF488A / IL2RA/2395

Product Details
Supplier Biotium
Catalog #: BNC882395-500 (View supplier product page)
Size 500 μl
Price $551.00
Antigen CD25
Clone IL2RA/2395
Host Mouse
Isotype IgG2b
Conjugate CF488A
Target Species Human
Applications IHC, IHC FFPE
Description CD25/ IL2RA (Activated Lymphocyte Marker) (IL2RA/2395), CF488A conjugate, 0.1mg/mL
About CD25 and CF488A
CD25 The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. Patients with severe Coronavirus Disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have significantly elevated levels of IL2R in their plasma. Similarly, serum IL-2R levels are found to be elevated in patients with different types of carcinomas. Certain IL2RA and IL2RB gene polymorphisms have been associated with lung cancer risk. [provided by RefSeq, Jul 2020]
CF488A CF®488A from Biotium is a fluorophore with an excitation peak at 490 nm and an emission peak at 515 nm. It is spectrally similar to Fluorescein, Alexa Fluor™ 488 and DyLight™ 488. It can be use in fluorescence microscopy and flow cytometry. In microscopy, CF®488A has been specifically validated for STORM, STED, Structured Illumination (SIM), 2-Photon microscopy and TIRF.
Citations
Additional
Sources
Reviews & Ratings
Submit a Review

CF488A Excitation and Emission Spectra