CD45 / CF405M / PTPRC/1783R PTPRC/1975R

Product Details
Supplier Biotium
Catalog #: BNC052026-500 (View supplier product page)
Size 500 μl
Price $459.00
Antigen CD45
Clone PTPRC/1783R PTPRC/1975R
Host Rabbit
Isotype IgG
Conjugate CF405M
Target Species Human
Applications IHC-P
Description CD45 / LCA Recombinant Monoclonal Rabbit Antibody (PTPRC/1783R + PTPRC/1975R)
About CD45 and CF405M
CD45 The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
CF405M CF®405M from Biotium is a fluorophore with an excitation peak at 408 nm and an emission peak at 452 nm. It is spectrally similar to Pacific Blue, V450 and DY-415. It can be use in fluorescence microscopy and flow cytometry. Specifically, it has been validated for use in STED, Structured Illumination (SIM) and 2-Photon microscopy. In flow cytometry, superior alternatives are Brilliant™ Violet 480, Brilliant™ Violet 510 and StarBright Violet 515.
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CF405M Excitation and Emission Spectra