CD263 / PE / DJR3

Citations: (1)
Product Details
Supplier Miltenyi Biotec
Catalog #: 130-124-904 (View supplier product page)
Size 30 tests in 60 µL
Price $120.00
Antigen CD263
Clone DJR3
Host Mouse
Isotype IgG1,κappa
Conjugate PE
Target Species Human
Applications FC
Description Clone DJR3 recognizes the human CD263 antigen, a glycophospholipid-anchored cell membrane protein which is also known as TNF-related apoptosis-inducing ligand receptor 3 (TRAIL-R3) or tumor necrosis factor receptor superfamily member 10C (TNFRSF10C). CD263 is the receptor for the cytotoxic ligand TRAIL. It lacks a cytoplasmic death domain shared by several members of the TNF receptor superfamily and hence is not capable of inducing apoptosis. CD263 is highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung, and heart. It is higher expressed in normal tissues than in tumor cell lines.
About CD263 and PE
CD263 The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008]
PE Phycoerythrin (PE, R-PE) is a red-emitting fluorescent protein-chromophore complex that can be excited the 488-nm blue, 532-nm green, or 561-nm yellow-green laser with increasing efficiency and captured with a 586/14 nm bandpass filter. PE has an excitation peak at 565 nm and an emission peak at 578 nm. PE is 240kD in size and has an extinction coefficient of ~2x10^6 which makes it one of the brightest fluorophores available and a potent donor upon which to build tandem fluorophores with longer Stoke's Shifts.
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PE Excitation and Emission Spectra