MART-1 / DyLight 594 / SPM555

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-34797DL594 (View supplier product page)
Size 0.1 ml
Price $519.00
Antigen MART-1
Clone SPM555
Host Mouse
Isotype IgG1 κ
Conjugate DyLight 594
Target Species Canine, Human, Mouse, Rat
Applications WB, ELISA, IHC, ICC/IF, IHC-P, IHC-Fr
Description This antibody recognizes a protein doublet of 20-22kDa, identified as MART-1 (Melanoma Antigen Recognized by T cells 1) or Melan-A. MART-1 is a newly identified melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. Seven other melanoma associated antigens recognized by autologous cytotoxic T cells include MAGE-1, MAGE-3, tyrosinase, gp100, gp75, BAGE-1, and GAGE-1. Subcellular fractionation shows that MART-1 is present in melanosomes and endoplasmic reticulum. This MAb labels melanomas and other tumors showing melanocytic differentiation. It is also a useful positive-marker for angiomyolipomas. It does not stain tumor cells of epithelial, lymphoid, glial, or mesenchymal origin.
About MART-1 and DyLight 594
MART-1 Located in endoplasmic reticulum membrane; melanosome; and trans-Golgi network. [provided by Alliance of Genome Resources, Apr 2022]
DyLight 594 DyLight™ 594 has an excitation peak at 593 nm and an emission peak at 618 nm and is spectrally similar to Alexa Fluor™ 594 and Texas Red. DyLight™ 594 is most commonly used in flow cytometery and fluorescence microscopy applications.
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DyLight 594 Excitation and Emission Spectra