ErbB3 / DyLight 488 / 138

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-90769G (View supplier product page)
Size 0.1 ml
Price $518.00
Antigen ErbB3
Clone 138
Host Rabbit
Isotype IgG
Conjugate DyLight 488
Target Species Mouse
Applications ELISA
Description Rabbit ErbB3/Her3 antibody [DyLight 488] detects Mouse
About ErbB3 and DyLight 488
ErbB3 This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
DyLight 488 DyLight™ 488 has an excitation peak at 493 nm and an emission peak at 518 nm and is spectrally similar to Alexa Fluor™ 488, fluorescein and FITC. DyLight™ 488 is most commonly used in flow cytometery, and fluorescence microscopy applications.
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DyLight 488 Excitation and Emission Spectra