ErbB3 / DyLight 405 / 28

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-90767V (View supplier product page)
Size 0.1 ml
Price $518.00
Antigen ErbB3
Clone 28
Host Rabbit
Isotype IgG
Conjugate DyLight 405
Target Species Mouse
Applications ELISA
Description Rabbit ErbB3/Her3 antibody [DyLight 405] detects Mouse
About ErbB3 and DyLight 405
ErbB3 This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
DyLight 405 DyLight™ 405 has an excitation peak at 400 nm and an emission peak at 420 nm and is spectrally similar to Alexa Fluor™ 405 and Cascade Blue. DyLight™ 405 is most commonly used in flow cytometery and fluorescence microscopy applications.
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DyLight 405 Excitation and Emission Spectra