53BP1 / Alexa Fluor 700 / 6B3E10

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-25028AF700 (View supplier product page)
Size 0.1 ml
Price $519.00
Antigen 53BP1
Clone 6B3E10
Host Mouse
Isotype IgG1
Conjugate Alexa Fluor 700
Target Species Human
Applications WB, FC, IHC
Description Mouse 53BP1 antibody [Alexa Fluor 700] detects Human
About 53BP1 and Alexa Fluor 700
53BP1 This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
Alexa Fluor 700 Alexa Fluor™ 700 (AF700, Alexa 700) has an excitation peak at 702 nm and an emission peak at 723 nm, and is spectrally similar to iFluor® 680 (ATT Bioquest) and iFluor® 700 (ATT Bioquest). Alexa 700 is commonly used in Flow Cytometry and is similar in size, brightness and application to iFluor® 700 and Vio® R720.
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Alexa Fluor 700 Excitation and Emission Spectra