PRDM9 / Biotin / Monoclonal

Product Details
Supplier Thermo Fisher Scientific
Catalog #: 730071 (View supplier product page)
Size 100 μg
Price $280.00
Antigen PRDM9
Clone Monoclonal
Host Mouse
Isotype IgG1
Conjugate Biotin
Target Species Human
Applications IP
Description PRDM9 Monoclonal Antibody, Biotin conjugate. The PR domain is a protein-protein interaction module of about 100 amino acids. PR domain-containing proteins, such as PRDM9, are often involved in transcriptional regulation.IP 2 ug
About PRDM9 and Biotin
PRDM9 The protein encoded by this gene is a zinc finger protein with histone methyltransferase activity that catalyzes histone H3 lysine 4 trimethylation (H3K4me3) during meiotic prophase. This protein contains multiple domains, including a Kruppel-associated box (KRAB) domain, an SSX repression domain (SSXRD), a PRD1-BF1 and RIZ homologous region, a subclass of SET (PR/SET) domain, and a tandem array of C2H2 zinc fingers. The zinc finger array recognizes a short sequence motif, leading to local H3K4me3, and meiotic recombination hotspot activity. The observed allelic variation alters the DNA-binding sequence specificity of the protein, resulting in distinct meiotic recombination hotspots amongst individuals and populations. Multiple alternate alleles of this gene have been described. [provided by RefSeq, Jul 2015]
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Biotin Excitation and Emission Spectra