CBL / Unconjugated / Poly6330
CBL / Unconjugated / Poly6330
Citations:
(1)
Product Details
| Supplier | BioLegend | |
|---|---|---|
| Catalog #: | 633001 (View supplier product page) | |
| Size | 125UL | |
| Price | $112.00 | |
| Antigen | CBL | |
| Clone | Poly6330 | |
| Host | Rabbit | |
| Isotype | IgG | |
| Conjugate | Unconjugated | |
| Target Species | Human, Mouse, Rat | |
| Applications | WB | |
| Description | Purified anti-Cbl |
About CBL and Purified
| CBL | This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Jul 2016] |
|---|
Images
|
Total cell lysates (15 µg protein) from HepG2 (Lane 1), HeLa (Lane 2), Raji (Lane 3), HEL (Lane 4), or RAW264.7 (Lane 5) cells were resolved using 4-12% Bis-Tris gel electrophoresis, transferred to nitrocellulose, and probed with purified anti-Cbl antibody (Poly6330) at a 1:1000 dilution. Proteins were visualized by chemiluminescence detection using HRP Donkey anti-rabbit-IgG (Cat. No. 406401) at a 1:3000 dilution. Equal protein loading was confirmed using Direct-Blot™ HRP anti-β-actin antibody (Cat. No. 643807) at a 1:5000 dilution (lower). Lane M: MW ladder. Cell lysates were loaded in order of increasing CBL mRNA expression levels (source: Human Protein Atlas). |
Citations
| Additional Sources |
|
|---|
Reviews & Ratings
Purified Excitation and Emission Spectra
$112.00
Supplier Page
Supplier Page
