CD80 / DyLight 405 / IDEC-114 (Galiximab)

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-81099V (View supplier product page)
Size 0.1 ml
Price $519.00
Antigen CD80
Clone IDEC-114 (Galiximab)
Host Human
Isotype IgG1 λ
Conjugate DyLight 405
Target Species Human
Applications WB, FC, ELISA, IHC
Description Galiximab is a primatized mAb which consists of human constant and primate (cynomolgus macaque) variable regions and binds specifically to B7-1/CD80. B7-1/CD80 is a surface glycoprotein and a member of the B7 family of costimulatory molecules. B7-1/CD80 antigen regulates T cell activation (through interacting with CD28 or CD152) and is expressed transiently in antigen-presenting cells, T cells and normal B cells, and expressed consitutively on various subtypes of B-cell lymphomas.
About CD80 and DyLight 405
CD80 The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011]
DyLight 405 DyLight™ 405 has an excitation peak at 400 nm and an emission peak at 420 nm and is spectrally similar to Alexa Fluor™ 405 and Cascade Blue. DyLight™ 405 is most commonly used in flow cytometery and fluorescence microscopy applications.
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DyLight 405 Excitation and Emission Spectra