CD27 / Janelia Fluor 549 / LG.3A10

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-81095JF549 (View supplier product page)
Size 0.1 ml
Price $519.00
Antigen CD27
Clone LG.3A10
Host Armenian Hamster
Isotype IgG κ
Conjugate Janelia Fluor 549
Target Species Mouse
Applications FC, ICC/IF
Description This antibody is specific for mouse CD27/TNFRSF7, which, as in the human system, is largely restricted to cells of the T cell lineage, and is expressed on the great majority of both alpha-beta and gamma-delta T lymphocytes, and thymocytes.
About CD27 and Janelia Fluor 549
CD27 The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]
Janelia Fluor 549 Janelia Fluor® 549 was developed at the Janelia Campus of the Howard Hughes Medical Institute but is commercialized by other vendors. The Janelia Fluor®s family is unique in that the fluorophores are cell-permeable and are available in photoactivatable forms. These fluorophores were developed for super-resolution microscopy (STED, PALM and STORM) and live-cell microscopy in the HaloTag and SNAP-tag versions. Janelia Fluor® 549 has an excitation peak at 549 nm and an emission peak at 571 nm.
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Janelia Fluor 549 Excitation and Emission Spectra