CD62L / Janelia Fluor 646 / MEL-14

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-81083JF646 (View supplier product page)
Size 0.1 ml
Price $519.00
Antigen CD62L
Clone MEL-14
Host Rabbit
Isotype IgG κ
Conjugate Janelia Fluor 646
Target Species Mouse
Applications FC, IHC
Description This antibody binds to mouse L-Selectin/CD62L the mouse peripheral lymph node homing receptor, which is a lectin-like cell surface protein rapidly down-regulated upon cell activation with phorbol 12-myristate 13-acetate.
About CD62L and Janelia Fluor 646
CD62L This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]
Janelia Fluor 646 Janelia Fluor® 646 was developed at the Janelia Campus of the Howard Hughes Medical Institute but is commercialized by other vendors. The Janelia Fluor®s family is unique in that the fluorophores are cell-permeable and are available in photoactivatable forms. These fluorophores were developed for super-resolution microscopy (STED, PALM and STORM) and live-cell microscopy in the HaloTag and SNAP-tag versions. Janelia Fluor® 646 has an excitation peak at 646 nm and an emission peak at 664 nm.
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Janelia Fluor 646 Excitation and Emission Spectra