EphA2 / HRP / 1C1

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-81069H (View supplier product page)
Size 0.1 ml
Price $519.00
Antigen EphA2
Clone 1C1
Host Human
Isotype IgG1 κ
Conjugate HRP
Target Species Human
Applications WB, ELISA
Description 1C1 binds specifically to the amino-termianal LBD (ligand-binding domain) region of the EphA2 ectodomain (IgG1 KD ~0.8 nM; Fab KD ~140 nM) and not to other related human Eph receptors such as EphA1, EphA2, and EphA4, or any EphB receptor family members.
About EphA2 and HRP
EphA2 This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.[provided by RefSeq, May 2010]
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HRP Excitation and Emission Spectra