AOC3 / DyLight 650 / TK8-14

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-81043C (View supplier product page)
Size 0.1 ml
Price $519.00
Antigen AOC3
Clone TK8-14
Host Rabbit
Isotype IgG κ
Conjugate DyLight 650
Target Species Human
Applications WB, FC, ELISA, IHC
Description Recognises human Vascular Adhesion Protein-1 (VAP-1/AOC3), a glycosylated homodimeric membrane protein consisting of two 90 kDa subunits connected by disulfide bonds. Epitope recognized by TK8-18 is present both in dimeric and monomeric forms of VAP-1/AOC3. Elevated soluble VAP-1/AOC3 serum- levels have been described in several inflammatory- diseases as well as colorectal cancer. TK8-14 is a function-blocking mAb.
About AOC3 and DyLight 650
AOC3 This gene encodes a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has adhesive properties as well as monoamine oxidase activity, and may be involved in leukocyte trafficking. Alterations in levels of the encoded protein may be associated with many diseases, including diabetes mellitus. A pseudogene of this gene has been described and is located approximately 9-kb downstream on the same chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]
DyLight 650 DyLight™ 650 is a red-emitting fluorophore that excited by the 640 nm laser and collected using a 670/30 nm bandpass filter. DyLight™ 650 has an excitation peak at 652 nm and an emission peak at 672 nm, and is spectrally similar to Alexa Fluor™ 647 and Cy5. DyLight™ 650 is most commonly used in flow cytometery and fluorescence microscopy applications.
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DyLight 650 Excitation and Emission Spectra