IL-18 / Alexa Fluor 532 / 125-2H

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-81040AF532 (View supplier product page)
Size 0.1 ml
Price $519.00
Antigen IL-18
Clone 125-2H
Host Rabbit
Isotype IgG κ
Conjugate Alexa Fluor 532
Target Species Human
Applications ELISA, ICC/IF
Description Recognizes the active form of human IL-18/IL-1F4.
About IL-18 and Alexa Fluor 532
IL-18 The protein encoded by this gene is a proinflammatory cytokine of the IL-1 family that is constitutively found as a precursor within the cytoplasm of a variety of cells including macrophages and keratinocytes. The inactive IL-18 precursor is processed to its active form by caspase-1, and is capable of stimulating interferon gamma production, and of regulating both T helper (Th) 1 and Th2 responses. This cytokine has been implicated in the injury of different organs, and in potentially fatal conditions characterized by a cytokine storm. In humans, IL-18 gene is located on chromosome 11. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2020]
Alexa Fluor 532 Alexa Fluor™ 532 (AF532, Alexa 532) has an excitation peak at 532 nm and an emission peak at 554 nm, and is spectrally similar to Cy®3 (GE Healthcare), TRITC, iFluor® 514 (ATT Bioquest) and iFluor® 546 (ATT Bioquest). Many flow cytometers are equipped with 532nm lasers, so while Alexa 532 can be used for flow cytometry, PE is more commonly used due to its brightness and spectral characteristics. This dye is commonly used for fluorescence microscopy applications.
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Alexa Fluor 532 Excitation and Emission Spectra