CD220 / Alexa Fluor 647 / 83-14

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-81038AF647 (View supplier product page)
Size 0.1 ml
Price $519.00
Antigen CD220
Clone 83-14
Host Rabbit
Isotype IgG κ
Conjugate Alexa Fluor 647
Target Species Bovine, Human, Porcine, Sheep
Applications WB, ELISA, IHC, ICC/IF
Description Recognises the extracellular domain of the Insulin R/CD220. Amino acids 469 - 592 (exon 7 and 8) of Insulin R/CD220.
About CD220 and Alexa Fluor 647
CD220 This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Alexa Fluor 647 Alexa Fluor™ 647 (AF647, Alexa 647) has an excitation peak at 650 nm and an emission peak at 665 nm, and is spectrally similar to Cy®5 (GE Healthcare), iFluor® 647 (ATT Bioquest), and DyLight™ 650 (Thermo Fisher Scientific). Alexa 647 is commonly used for flow cytometry, microscopy, super-resolution microscopy applications. It is very bright, photostable, and pH insensitive, all of which contribute to sensitive detection while using this dye.
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Alexa Fluor 647 Excitation and Emission Spectra