Bestrophin 1 / Unconjugated / E6-6

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-80593 (View supplier product page)
Size 0.1 ml
Price $459.00
Antigen Bestrophin 1
Clone E6-6
Host Mouse
Isotype IgG1 κ
Conjugate Unconjugated
Target Species Canine, Human, Porcine, Primate, Rat (Negative)
Applications WB, IHC, ICC/IF, IP, IHC-P, IHC-Fr
Description Human, Primate, Porcine reactivity reported in scientific literature (PMID: 11050159).
About Bestrophin 1 and Purified
Bestrophin 1 This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Nov 2008]
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Purified Excitation and Emission Spectra