Vitamin D Receptor / Unconjugated /

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: H00007421-B01P (View supplier product page)
Size 50 μg
Price $399.00
Antigen Vitamin D Receptor
Clone
Host Mouse
Isotype IgG
Conjugate Unconjugated
Target Species Human
Applications WB, ICC/IF
Description VDR - vitamin D (1,25- dihydroxyvitamin D3) receptor,
About Vitamin D Receptor and Purified
Vitamin D Receptor This gene encodes vitamin D3 receptor, which is a member of the nuclear hormone receptor superfamily of ligand-inducible transcription factors. This receptor also functions as a receptor for the secondary bile acid, lithocholic acid. Downstream targets of vitamin D3 receptor are principally involved in mineral metabolism, though this receptor regulates a variety of other metabolic pathways, such as those involved in immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Jun 2018]
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Purified Excitation and Emission Spectra