DCTN1 / Unconjugated / 705007

Product Details
Supplier R&D Systems
Catalog #: MAB6657-SP (View supplier product page)
Size 25 μg
Price $149.00
Antigen DCTN1
Clone 705007
Host Mouse
Isotype IgG2b
Conjugate Unconjugated
Target Species Human, Mouse
Applications WB
Description Human/Mouse Dynactin Subunit 1/DCTN1 Antibody
About DCTN1 and Purified
DCTN1 This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq, Oct 2008]
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Purified Excitation and Emission Spectra