CD235a / PE / REA1092

Citations: (1)
Product Details
Supplier Miltenyi Biotec
Catalog #: 130-118-606 (View supplier product page)
Size 200 μl
Price $315.00
Antigen CD235a
Clone REA1092
Host Human
Isotype IgG1
Conjugate PE
Target Species Human
Applications MICS (MACSima Imaging Cyclic Staining), IF, IHC
Description Clone REA1092 recognizes CD235a, the major intrinsic membrane protein of erythrocytes, also known as glycophorin A. CD235a is a single-pass transmembrane glycoprotein and is expressed on mature erythrocytes and erythroid precursor cells.CD235a is a receptor for Hepatitis A virus and plays an important role in translocation of SLC4A1 to the plasma membrane. | Additional information: Clone REA1092 displays negligible binding to Fc receptors.
About CD235a and PE
CD235a Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. In addition to the M or N and S or s antigens that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta, as well as Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. [provided by RefSeq, Jul 2008]
PE Phycoerythrin (PE, R-PE) is a red-emitting fluorescent protein-chromophore complex that can be excited the 488-nm blue, 532-nm green, or 561-nm yellow-green laser with increasing efficiency and captured with a 586/14 nm bandpass filter. PE has an excitation peak at 565 nm and an emission peak at 578 nm. PE is 240kD in size and has an extinction coefficient of ~2x10^6 which makes it one of the brightest fluorophores available and a potent donor upon which to build tandem fluorophores with longer Stoke's Shifts.
Citations
PMID 1391951
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PE Excitation and Emission Spectra